Washington State University researchers say ancestral exposures to environmental compounds like the insecticide DDT may be a factor in high rates of obesity. The finding comes as DDT is getting a second look as a tool against malaria.
What your great-grandmother was exposed to during pregnancy, like DDT, may promote a dramatic increase in your susceptibility to obesity, and you will pass this on to your grandchildren in the absence of any continued exposures,” says Michael Skinner, WSU professor and founder of its Center for Reproductive Biology. He and his colleagues document their finding in the current issue of the journal BMC Medicine.
When Skinner and his colleagues exposed gestating rats to DDT, they saw no altered rates of obesity in the parent or first generation of offspring. But the disease developed in more than half the third-generation males and females. The researchers say the insecticide may be affecting how genes are turned on and off in the offspring of an exposed animal, even though its DNA sequences remain unchanged.
This is called transgenerational epigenetic inheritance. In recent years, the Skinner lab has documented epigenetic effects from a host of environmental toxicants, including plastics, pesticides, fungicides, dioxins, hydrocarbons and the plasticizer bisphenol-A or BPA.